The Tampa Bay Buccaneers have been without starting quarterback Josh Freeman for the past two games after he suffered a torn anterior cruciate ligament in his left knee.
The Bucs are now without McCown, who has been out since Oct. 6.
McCown has been a solid starter during his three-year career with the Bucs, completing 68.5 percent of his passes for 3,976 yards, 22 touchdowns and seven interceptions in eight games.
He has thrown six touchdown passes and no interceptions in three games.
The Buccaneers are 4-2 after the loss.
McCOWN’S RANKING OF QBS BY DATE WEEK 5 QB QB rating Week 5 QB rating Josh McCraw -9.4 McCown ranks second in the NFL in passing efficiency, completing 67.5 of 80 passes for 1,890 yards and 13 touchdowns.
McCraw ranks second on the Bucs with a passer rating of 158.9, third in passing yards per attempt and fourth in passing touchdowns.
The 49ers are 5-1 after a road win at Seattle on Sunday.
QB RB RB rating Week 4 RB RB RB Josh McCrew 1.8 Josh McCread ranks second with a rushing touchdown, passing touchdown, rushing yardage and rushing touchdowns.
He ranks second among running backs in rushing yards and first in rushing touchdowns among active players.
The Packers are 4, 9-4 after a win at Minnesota on Sunday, but they also are 3-4 when McCown isn’t in the lineup.
QB QB ratings Week 5 Quarterbacks QB rating QB rating Aaron Rodgers 1.5 Aaron Rodgers ranks second behind Matt Ryan with a rating of 118.4.
Rodgers has thrown for 1.9 touchdowns, one more than his previous best of 1,863 yards in a game in Week 3.
The Green Bay Packers are 5, 10-4, and are in third place in the NFC North.
WR WR WR rating Week 3 WR WR Michael Floyd 1.6 WR Michael Florence is third with a total of 11 catches for 104 yards and a touchdown.
Floyd has caught 11 passes for 143 yards and three touchdowns.
WRs WR1 WR1 Corey Coleman 1.3 WR Corey Coleman ranks fourth with six catches for 102 yards and two touchdowns.
TE TE Jermaine Gresham 1.2 TE Jermel Jones ranks fifth with four catches for 33 yards and no scores.
RB RB Aaron Jones 1.1 RB Aaron Gordon is sixth with 1,095 yards rushing, fourth with 12 touchdowns and tied for third with eight rushing touchdowns and five rushing touchdowns from scrimmage.
TE Matt Breida 1.0 TE Matt Bretts is tied for fifth with eight catches for 67 yards and one touchdown.
WR TE Greg Olsen 1.4 WR Greg Olsen ranks seventh with four receptions for 39 yards and zero touchdowns.
RB James Starks is tied with RB Adrian Peterson for sixth with a career-high 3,074 yards rushing.
TE Maxx Williams 1.7 TE Max Wittek ranks eighth with two receptions for 19 yards and none of his career-long totals.
WR1 QB Josh McCorkell 1.05 QB Josh Bradford is tied fourth with 10 touchdown passes, his first of the season.
McCorck is 10-of-19 for 151 yards and four touchdowns.
LB LB Justin Durant 1.25 LB Justin Davis is tied fifth with seven tackles, three tackles for loss and a forced fumble.
DE DE Calais Campbell 1.12 DE Calais Atkins is tied sixth with three sacks, one quarterback hit and one forced fumble and is fifth in the league with four forced fumbles.
TE Ryan Taylor 1.03 TE Ryan Fitzpatrick is tied ninth with three catches for 42 yards and an interception.
RB Michael Turner is tied 10th with 38 yards rushing and one rushing touchdown.
DE Jason Hatcher is tied 13th with four tackles, one sack, two tackles for a loss and an assist.
TE Cameron Artis-Payne is tied 15th with five catches for 71 yards and five receiving touchdowns.
OLB Joey Bosa is tied 14th with 10 tackles, two sacks, two hits and a quarterback hit.
CB Malcolm Jenkins is tied 17th with seven passes defended and two interceptions.
DE Cameron Wake is tied 18th with three pass breakups, one interception and a sack.
OL Brandon Spikes is tied 19th with two pass break ups, one pass breakup and a pass breakup.
LB David Mayo is tied 20th with a sack, one forced fumble and one pass break up.
FS DeAngelo Hall is tied 22nd with four pass break-ups and two passes defended.
LB Brandon Boykin is tied 23rd with five pass break points.
LB Chris Jones is tied 24th with one tackle for loss.
LB Jon Bostic is tied 25th with six tackles, four pass breakup, one assist and one quarterback hurry.
DB Jalen Ramsey is tied 26th with 11 pass break tackles and two pass defended.
DE Anthony Walker is tied 27